I have them both (starting to get interested in desktop publishing) and I can truly say that I really like InDesign better. I can do so much more, and because I know how to use Photoshop and Imageready really well, I started InDesign knowing at least some knowledge. I like the way it works better, the way it handles images, etc. I also think it exports to PDF easier and nicer, with the PDF Presets. I can produce a quick draft PDF of my newsletters and easily show them to anyone. I did like starting out on Quark, with the simple tools and layout of the program, but once I got REALLY into it, I started to see all the additional settings, etc I could do in InDesign, and I don't plan on using Quark anymore.