For now, I'm worried about a more specific case of putting World of Warcraft on an external USB hard drive, but I suppose this applies to everything else as well. I want to offload WoW onto my external hard drive so it doesn't consume precious internal hard drive space on my Macbook. However, I'm worried about things getting screwy with the settings or whatever as soon as I use AppZapper on the internal hard drive copy of World of Warcraft and then try to launch WoW off of my external hard drive. In any case, should I even be worried about this? Are most Mac applications self contained to the extent that I can be sure that there won't be any sort of orphaned links or whatever between the application and the system when I move the application somewhere else?