Yes: Basically, don't worry about it, let OSX manage its own memory.
There's only one thing you should montior, and that is the PageOut/PageIn ratio. The absolute numbers don't mean much but if the ratio of Outs to Ins gets above 5%, keep an eye on it. If it goes above 10 - 15%, that means you are regularly exceeding the amount of physical RAM you have , and the machine is being slowed down by frequent writes to the hard drive to accommodate the overflowed RAM. At that point consider installing more memory.