My understanding is that those are the printer drivers for all the printers that you may possibly ever connect a Mac too. If we are talking about the same folder, then you should see lots of sub-folders inside that have printer company names. I believe its safe to delete all those sub-folders - except - for the printer you are actually using.
There is also a free download called Monolingual (Get it, among other places, at MacUpdate). It will remove a bunch of unneeded printer drivers, language files, etc to free up gobs of space. I've used it, and haven't found any issues.