I've played quite a bit with the iMac 5K in the local Apple store, and decided I wanted a display that good for my cMP 2010. The iMac 5K display is amazing.
I purchased a flashed 7970 from MVC, and replaced the stock HD 5770 graphics card.
[I have no interest in fiddling with Nvidia drivers for Mac OS. The HD 7970 was more than enough for my goal, which is simply 4K UHD on a decent monitor with the 2010 cMP. I ran the new 7970 with my old (non 4K) monitor for a few weeks, never a glitch, everything ran completely normal]
Anyway, I paired the 7970 with a Dell P2715Q 4K display, and am blown away by the display quality. It is the equivalent of nearly any Apple Retina display - the pixels are not visible with your naked eye. I get the full resolution at 60Hz using a mini-displayport to displayport cable.
Not all is peaches and cream though. With the 7970 card flashed from MVC, and Dell P2715Q pair: (Yosemite 10.10.5, 6 core 3.33Ghz classic MP 2010, 24G)
1) As far as I can tell, you will never, ever see a boot screen with the Dell 4K monitor attached. If you have a "normal" monitor attached (2560x1600 or less), you will see a boot screen, the Apple logo, etc. This is what a "flashed" card gets you - the boot screen with a normal monitor.
2) To power up or restart the cMP with 4K monitor attached, the monitor must be initially off. When you hear the startup chime, then turn the monitor on. Everything is fine after that, the 4K display comes up, etc.
3) If you restart the cMP, or power up the cMP, with the Dell 4K powered up, all you get is the start up chime every second or two forever. The Dell 4K must be off when the cMP is restarted or powered up. Otherwise, it just sits there, chiming away every second or two...
4) Sleep works fine. If the display sleeps, hit a key and everything is fine. If the cMP is asleep, hit a key, the cMP fully powers up, and everything is fine.
I didn't test anything with two monitors attached (like the Dell 4K and a normal monitor...) Your mileage will vary with display, display card, etc.
It's worth the hassle though. The Dell P2715Q display on the cMP is amazing. The 7970 might even be able to drive two of them..