Yes, it works; however, at least mine requires that I lift the left finger off the mouse surface before pressing the right finger, so I had little trouble getting used to it. The scroll wheel is outstanding!
Except for no 8 way scrolling. You can get sideways by holding down CTRL when you scroll up or down. But I'd still like to see a driver for the 8 way scrolling. Not sure if XP even supports that........*friggin xp*
I used a Mighty mouse with an iMac recently and it felt pretty good. I didn't have a problem right clicking...I guess I naturally lift my left finger when I right click...