Hey, It is the second time that my rMBP doesn't wake up from sleep. The only application that I've recently installed are Alferd and BetterTouchTool - Could it have something to do with that? In addition it happened twice only after long time sleep of like 8 hours - if I sleep the machine now and wake it after 2 minutes it wakes up perfectly. Do you have any ideas what can cause this? In Lion I had no problems. EDIT: Apple released the following update http://support.apple.com/kb/DL1559 hopefully this will fix the problem. FINAL EDIT: Fixed the problem by formatting the partition and freshly installing ML.