1. Disable all extensions. May be one of them is not compatible with 10.14.5 version of Safari. May be there are updated versions?
2. Create a new user and try to run Safari there, that will tell you if this is system wide or user specific.
3a. If it is system wide, I would reinstall 10.14.5 using combo installer. Ideally, I would reinstall just Safari, but I think this is the only way to reinstall Safari.
3b. If it is user specific, something is wrong with Safari specific setup in that user account. What, not sure. Clean cache seems good idea, remove extensions,...
Before you do ANYTHING., backup your computer.