If it works in a new user account then doing a clean install won't resolve the issue if your restore your user account from a time machine backup because you will be copying back the same files you have now in your account. Something in your user account is corrupted. Try this:
- Exit Safari.
- Hold down the option-key, select "Go" from the menubar, select "Library".
- In the finder window drag the "Safari" folder to you desktop.
- In the finder window, select "Preference" folder, drag "com.apple.Safari.plist" and "com.Apple.Safari.Extensions.plist" to your desktop.
- Open System Preferences->Users and Groups.
- Select the "Login Items".
- Remove all items listed.
- Reboot and login again. Now try Safari and see if the issue still exists.