no probs, its a laptop basically thats what its meant to do (either use on your lap, on your bead, on a shaky car, or on a turbulent plane, if you had a perfectly flat surface to use your computer all the time you would have bought a iMac wouldnt you??) the HDD is protected with sudden motion sensors and are pretty rugged (dont drop the laptop to test it please...) and even if they do fail over a prolonged period of abuse... then you just change it, HDDs are very cheap (however is unlikely this would to happen as the computer has a sudden motion sensor that works fairly well and laptop HDDs actually are pretty good with G forces... However about the heat.... well I have no a definitive answer since MBPs are designed to run well at high temperatures, my guess is that as long as the fans are lower than 6K rpm then the system is running at a "safe" temperature (though safe temperature could mean that if you are using the laptop on your lap you are taking the risk of killing your future children

) but I doubt you could possibly do something intensive enough while in bed, to heat the computer to such extent (you'd probbably be browsing internet or watching a video... i dont think someone could actually use photoshop or play a game or video edition while on the bed but you know, there is always weird people.)