Hey all, Just received my Retina MacBook Pro but have been suffering from this same issue on my Air as well. Basically, I use both the trackpad and a wireless mouse. Wireless Mouse - Uncheck "Scroll Direction: natural" Trackpad - Check "Scroll Direction: Natural" In effect, you can't have one setting for the mouse and another for the trackpad (that would make wayyyy too much sense, right Apple?). So I am constantly changing it depending on which tracking solution I use. Does anyone else have this issue, and if so, how do you combat it without changing it every time?