Definitely could (well with a keyboard and mouse). It's what I use and my MBA is my machine for everything. I've got a 24" 1920*1200 and it works a treat. Am considering Thunderbolt display very much so! If you intend to use it for games then just go for an iMac as the MBA isn't great with games and nor too will the MacMiniiv got the 2011 256gb 1.8 model so you reckon i could get away with just having a large display?