I upgraded my wife’s computer to Tahoe from Sierra and her email program last one of its accounts. I tried to reinstall it, but it kept locking up so I called Apple tech-support. After a half an hour of troubleshooting with the tech support person he told me that Tahoe only supports one iCloud address for mail so I couldn’t use both her iCloud accounts for mail. I had to restore the computer and put it back to Tahoe. That was fun.
Currently have 7 different iCloud email addresses working in Tahoe. They've all always worked the whole time.