Chiming in with my NO - Drobo Dashboard launches and shows the Drobo, but trying to mount a share is broken by Sequoia. I was using my Drobo as a Time Machine for several Macs and all the upgraded Sequoia machines give errors that the "drive disconnected during backup". The non-Time Machine shares can be mounted for a minute or so before disconnecting.
I'm looking at Synology and TerraMaster...