Become a MacRumors Supporter for $50/year with no ads, ability to filter front page stories, and private forums.
How long has the machine been on?

Still sluggish after a restart.

---

Edit: Run update_prebinding and repair permissions, if it happened after an Software update.
 
I was having a similar problem. It turns out some system files were corrupted. Try an archive & install from the OS disk. Should be fine after that.
 
Register on MacRumors! This sidebar will go away, and you'll see fewer ads.