Just tried starting Word and nothing happened. Then tried other Office X apps, Excel and Powerpoint, and nothing. Trashed a few plist files, used Onyx to repair permissions etc, restarted and still the same. Then tried Photoshop, Dreamweaver, Imageready and they don't start either (nor do they when I try an Open With.... or a dble-clk on a document). InDesign and Illustrator start and run ok, so do things like MacENC (gps navigation software), Onyx, Firefox and other 3rd party stuff. Also all the Apple apps like Safari, iPhoto, AddressBook, Mail etc are ok. I have a backup on an external drive, which (of course!) isn't quite up to date, so I'm a bit loathe to go down that route just yet. Any suggestions would be gratefully received.