My MacPro 2.66 installed a 8800GT in slot 1(using PCI-E x16) and old 7300GT move to Slot 4 (x8)。They work fine on 10.5.2。But after updated to 10.5.3-10.5.5. There have some problems. 
1. Time Machine background change to white
2. The "Translucent Menu Bar" in Desktop & Screen Saver lost.
Config: Mac Pro 2.66
7300GT on Slot 4 (x8) and 8800GT for 1st gen (bought from Apple Online Store )on Slot 1 (x16).
8800GT port A : Dell 2407wfp
8800GT Port B: Samsung 930BF
7300GT Port A: Philips 190B
OS: 10.5.3-10.5.5 have same problem
1. Time Machine background change to white
2. The "Translucent Menu Bar" in Desktop & Screen Saver lost.
Config: Mac Pro 2.66
7300GT on Slot 4 (x8) and 8800GT for 1st gen (bought from Apple Online Store )on Slot 1 (x16).
8800GT port A : Dell 2407wfp
8800GT Port B: Samsung 930BF
7300GT Port A: Philips 190B
OS: 10.5.3-10.5.5 have same problem