I want to upgrade the RAM of my Mac Pro 5,1 3.33Ghz. On everymac.com it says this about the memory: *Four memory slots are provided on the "slide out" processor tray. Note that this model supports triple channel memory addressing and performance is improved by installing memory in groups of three. - Max 48GB Does that mean that 3 x 4GB is better than 4 x 4GB. And 3 x 8GB better than 4 x 8GB? Why the 4 slots then and not three? I want to eventually get to 48GB (3 x 16GB) so I think I'll start with 1 x 16GB. Are there any negatives to having 1 Dimm of 16GB when it says it's best to keep them in groups of three?