Just to let ya know you the 4GB of ram should be plenty with PS3, I tried to max out mine and PS would only pull off 1.8GB with a 1.3GB file. There does seem to be a patch on adobe.com that fixes it so PS uses the extra ram for big files. I have also heard of making a Ramdrive to use as a scratch, however if the adobe patch does the same thing you can eliminate the ramdrive hogging space. I really dont worry about it because I rarely go bigger than a 21mp image with a couple raster layers (lots of Adj. layers though!) The 1.3GB PSB file was merely a test file enlarged to a gargantuan size.
I came close to paging out when I was working on my senior project with Photoshop, Indesign, Illustrator, Bridge, Safari, Mail, and iTunes (a very productive app 🙂 ) running all at once.
As far as the partitioning, I have heard even if you have one disk, it gets better performance if you have a partition a section just for scratch so that its clear and unfragmented. If your looking for a fast disk setup you could put together a couple of drives and make a Raid 0 setup, try it without the raid scratch first, you might not need it. I am very happy with a 7200rpm scratch, very rare do I have to wait for a filter to apply.