Yes, each chip is handmade. They require people with tiny hands to lay out each one. Which is why they employ children (and elves when they are available). This is also why there's a backlog of iPhone 5s, as it can take weeks to months to make each chip. So if you place an order now, it could take many months before the chipmaker gets to your order. But rest assured, that chip will be handmade to your exact specifications. That's the luxury of a bespoke chip.
They are also required to have exceptional eyesight and motor control with which they can manipulate circuits on a 32nm level.