Every day or so I end up with a couple of apps that won't launch (or rather, won't quit), citing something like... ..when trying to relaunch the app, requiring a restart to be able to use the app again (with no issues). Mac mini intel core duo, 1.6ghz, 2gb ram, latest Leopard, all that. iTunes is actually not the only app that does this, afaik so far the list's included Finder, Disk Utility, Terminal, Xcode, Colloquy, Adium, NetNewsWire, Instruments.app, Transmit, Safari...you get the idea. The other day I actually ps'd it (in terminal) and it said that the application in question was trying to quit, so I stupidly kill -9'd the ppid thinking that would work, which for that app happened to be launchd, which was pretty stupid on my part (to be fair, i thought launchd was pid 1, i didn't know there was going to be more than one launchd process - i killed the one for my user). So it seems the app won't quit, and I haven't found a way around that. I thought this was a hard drive issue..and subsequently discovered that the internal drive on my mac mini was failing (yay for SMART status) and I thought that was why these problems were happening. But even after a new hard drive, no such luck. I googled around and found http://forums.macrumors.com/showthread.php?t=498969 on these forums, checked the ram, no problems there. Apple Hardware Test, no problems there. Unfortunately http://docs.info.apple.com/article.html?artnum=307001 was one of the other google results, and I wouldn't touch ContentBarrier with a ten foot pole, so that's not the problem... I've already reinstalled Leopard about three times now, permissions check, fsck..it's getting pretty annoying now. I'm out of ideas. Heeeellllpp! edit: Also for what it's worth, it's been running Tiger with no such issues until I came back home from WWDC and I installed Leopard. The problems seemed to start happening after having installed Leopard for the first time on this machine..