I AM AWARE THAT I HAVE OTHER THREADS ABOUT THIS SAME ISSUE. BUT NOBODY GAVE ME USEFUL INFO. SO THIS TIME I WILL MAKE MY ISSUE A LITTLE MORE CLEAR. I have a macbook pro running os x Yosemite with 4 GB of ram and 440 GB of available storage space on the hard drive. My problem is that my applications do not work. When I start them, I get the spinning beachball and the program becomes unresponsive. This has been going on for a long time. But one day I tried to open Photo Booth. as usual it was unresponsive and didn’t open. But I then started to write some essays and I forgot I tried to open Photo Booth without force quitting it. All of a sudden, Photo booth popped up. I don’t know how long I left it there. Maybe an hour or 2. But when Photo Booth opened, ALL of my other applications started working. The problem with this is that if I restart or close photo booth, everything will become unresponsive again. But after some time I eventually had to restart my mac because finder kept freezing. I tried opening photo booth and leaving it there. But this time I have left it open for a whole night and still nothing. I know my issue is not a failing hard drive because FOR SOME REASON MY APPLICATIONS WORK IN SAFE BOOT. This time, To provide more information, here are a list of things I have tried to fix this problem: Opening applications in terminal Verifying and repairing disk permissions Removing ever application on my mac Creating another user account Reset PRAM Reset SMC Reinstalling os x and erasing everything Non of these have worked. So please give me a solution to this problem. Thanks in advance!