I had attached a couple of 500 GB drives inside of a fairly cheap enclosure to the AE, and after some massaging, (not officially supported by Apple) got Time Machine to work just fine backing up my MBP. I have a wireless printer, and don't worry about backing up my Windows machine, given that all of my important data is now on my Mac (see Apple servitude statement above). After a while the cheap enclosure went belly up and, rather than deal with another enclosure on the AE I just went all in with the 2TB Time Capsule. Hooked it up and it's been working flawlessly since.
But a NAS type solution, i.e. Time Capsule or AE with tethered USB drive, is really the way to go with a MacBook.