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Tom Petty died of an accidental overdose.
After months of speculation, a medical examiner has ruled that Tom Petty died of an accidental overdose, according to a statement from the Los Angeles County Medical Examiner. The Hall of Fame musician had taken several pain medications, including Fentanyl, oxycodone and generic Xanax. Other medications included generic Restoril (a sleep aid) and generic Celexa (which treats depression).

The coroner's office listed Petty's official cause of death as "multisystem organ failure due to resuscitated cardiopulmonary arrest due to mixed drug toxicity," noting the singer suffered from coronary artery atherosclerosis and emphysema.

Petty had been prescribed the drugs to treat emphysema, knee issues and a fractured hip, his family said in a statement accompanying the results. Petty's coronary artery disease had been a persistent problem throughout his final tour.
https://www.rollingstone.com/music/news/tom-pettys-cause-of-death-accidental-overdose-w515472
 
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