True tone on when i'm consuming content. Different story if one is creating content. Then you should have your display calibrated to a industry standard, example 6500k, 2.2 gamma, and also use your screen in a neutral environment in the first place. Studios etc use 50% neutral gray walls and no lamps to mess up with the eye sight.
I have a love hate relationship with True Tone. At times I like it but I do find that the white colors appear yellowish. If I keep using it then I like it but sometimes it just looks off and I turn it off. I kind of go back and forth depending on what I am doing and where.