Become a MacRumors Supporter for $50/year with no ads, ability to filter front page stories, and private forums.
TweetDeck is fairly good, albeit reduced in power and complexity with the recent update. But if all you want is to see multiple columns at once and set up searches for people/hashtags/etc, it's good enough.
 
I just use Twitter for its simplicity, gave tweet deck a try didn't like it as much though
 
The quote above was a great Thread. Plus, the poll was helpful in determining what is most popular.

Question....Can I use both the regular Twitter app and Tweetdeck at the same time?
Yes, you can. I don't see why you'd want to, but you can.
 
Register on MacRumors! This sidebar will go away, and you'll see fewer ads.