It took me hours to get Spore to install and work properly. Here is what I did:
- Install SPORE.
- Launch the Game but do not download patches.
- Quit the game.
- Download the first patch.
- Launch the game but do not download any more patches.
- Quit the game.
- Download 2 more patches.
- Launch the game but again, do not download any more patches.
- Quit the game.
- Launch the game and download the rest of the patches.
- Play!
The problem is if you haven't launched SPORE after installing it, any patch you download will break the game. The same goes for Patch 4 I think it is, you must launch the game before downloading the remaining patches.
After Googling for a long period of time and finding nothing, the above instructions is what worked for me.
If you have SPORE installed, delete it, delete the "SPORE Preferences" folder from Users > Username > Library > Preferences, restart and then follow the instructions.
Edit: I am using a Macbook Pro from June 2008 running 10.6.2 (Snow Leopard).