I've been told in the past by
@LightBulbFun that Photoshop (any version) does not leverage the full 16GB. I'm not sure about the other apps in the suite, but when I had my Quad G5 this was the case. And in large part is why I did what I quote below…
I was doing this with my Quad G5. I made about a 10GB ram disk and then I put my TenFourFox profile and the T4Fx app in the ram disk. That kept the browser, the cache and all the support files (extensions, etc) in ram. That was 5 years ago, but as AquaFox and PowerFox are both forks of Mozilla it is still possible.understanding is that after effects within cs4 suite specifically can leverage the full 16gb ram by running multiple instances, but you are correct that cs4 itself is 32bit primarily designed for 32bit systems of that era which limits how much ram it can use