Just been reading up on this a bit and it seems there are some issues with laptops (macs at least) getting really hot when hooked up to some firewire audio interfaces (probably not only a mac issue but not sure). Also been reading that USB 2.0's are actually really good, fast and in some ways possibly better/more convenient (ugh - I hope you don't ask for sources but I suppose I can find at least one). Ok here's one (scroll down to "firewire versus USB"): http://www.soundonsound.com/sos/nov03/articles/edirolua1000.htm But still...everyone loves firewire and more importantly, I'm leaning toward getting the Presonus Firebox just because it (and the Firepod) have such good reviews pertaining to macs - but not because it's firewire necessarily. Anyone care to chime in w/ their own opinions/experience/info? Thanks!