I forget when or how it started, but whenever I unplug and replug my Logitech MX310 in, USB Overdrive's settings are ALWAYS default until I run System Preferences. Then it returns to my settings. I don't know what the deal is. I have restarted, logged out, reinstalled, uninstalled then reinstalled, trashed preferences and re-entered everything, different USB ports... EVERYTHING. And USBOverdriveHelper is in my Login Items. I don't even have to click on the preference pane. I just have to open System Preferences and all the settings return. But I have to do this every time I plug the mouse in. As long as it's plugged in and I've run Sys Prefs, the settings will stay. Unplug and replug. The settings are defaulted until I run Sys Pref again. ARRRRRGH! This never happened on my iMac. What is the DEAL?! Me so annoyed.