Outside of consolidating both Internet accounts into the same profile so both your work and personal accounts show up in Mail, Contacts, Calendars, Reminders, you might look at downloading another mail application like Thunderbird(free) or Outlook for Mac to handle your other email account so they are not both showing up in Mail. Create another folder in Documents for saving work vs personal stuff. If you want them virtually separated (meaning they can't see each other) while being on the same screen, you might look into Virtual Box and virtual machines, although you will need to ensure that you have adequate space and computing resources to handle running another operating system on top of your running OS.