I watched the whole thing full-screen without any technical issues. I found it to be a really impressive presentation, perhaps one of the most significant keynotes of Jobs' impressive career. This is what he had wanted to do nearly 15 years ago, but didn't have the infrastructure for. As usual, he's driven Apple way out ahead of all the other PC and mobile companies. He knows the future is the "cloud" and he's made it happen.
The main thing that's kept me from using my iPad as my main computer is the hassle of saving and syncing, and the lack of copious storage. That will no longer be an issue. Ironically, the future lies in the past. One of my first tech jobs in the 1980s was working with a Wang system, where we all had dumb terminals. All the software and every document we created was synced to a central server. I've come full circle now, except that my office is the world.