Yes clamxav is probably a good one and it is free if you really feel you need some protection. I use it and run it when I remember which is like once a mouth or sometimes less Nd so far in over three years never found anything but good to have just in case I guess lol.....
Thing is; if we all ran the like of ClamXav, the chances of malicious code spreading and gaining traction will be very much limited; not all have a high level of computing experience, nor do they actually need to...
Trojan-Downloader:OSX/Flashback.I
Trojan-Downloader:OSX/Flashback.I is dropped by malicious Java applets that exploit the known CVE-2011-3544 vulnerability.
On execution, the malware will prompt the unsuspecting user for the administrator password. Whether or not the user inputs the administrator password, the malware will attempt to infect the system, though entering the password will affect how the infection is done.
If infection is successful, the malware will modify the contents of certain webpages displayed by web browsers; the specific webpages targeted and changes made are determined based on configuration information retrieved by the malware from a remote server.
Installation
On execution, the malware checks if the following path exists in the system:
/Library/Little Snitch
/Developer/Applications/Xcode.app/Contents/MacOS/Xcode
/Applications/VirusBarrier X6.app
/Applications/iAntiVirus/iAntiVirus.app
/Applications/avast!.app
/Applications/
ClamXav.app
/Applications/HTTPScoop.app
/Applications/Packet Peeper.app
If any of these are found, the malware will skip the rest of its routine and proceed to delete itself.
It`s speculated that some 600K Mac`s have been infected to date, that alone is 600,000 reasons to run ClamXav. I rarely run a manual scan and limit ClamXav`s sentry to a few specific folders, with scheduled scans taking place in the small hours. Had this code contained a malicious payload these Mac`s would have been directly affected...
Personally I dont understand people`s reluctance, it`s like a badge of honour "Mac`s are virus free" and yes to a point they are; it`s just code someone soon is going to work it out, just look at the advancement in malware attacks specifically for OS X. I also agree with sensible computing habits you can be safe, equally a trusted site can be compromised and become a threat overnight.
To have a free, low headroom, accorate scanner that offers a lot of flexibility and not utilize it seems a little stubborn. The retorts of AV being a resource hog, boils down to one thing, research; ClamXav will not bog your system down, if it does you have some other inconsistencies that need addressing, or your hardware is so old it`s well and truly time to upgrade, on my Early 2008 MBP ClamXav is simply invisible, there is absolutely no degradation of performance, as for the new i7 2.4

it`s transparant guy`s...
I have literally decades of work on my systems, I have no intention of losing any data, ClamXav is but one tool in a multilayered safety net. Lets face it if and when OS X is compromised it will spread like wildfire as many fundamentally believe that OS X is invulnerable, and I am not entirely sure posts that overly build a sense of security are helpful to the basic user, even Apple recognise the threat, however the updates are too slow to be considered a preventative measure...
BTW I have no association with ClamXax, Same principle as a condom. I'd rather have one and not need it, than need it and not have one
Q-6