I use iTap VNC and after I installed Lion, it stopped working. The developer issued an update a few days later and the login worked but I couldn't click on anything. I spent days emailing back and forth with the developer and they couldn't reproduce the problem. I read forum after forum with users complaining about various VNC clients that stopped working under Lion but were all working again. I came this close to coughing up $20 for "Screens" because so many users said it was working. I also found a forum post that said some "encodings" changed with Lion and I tried them to no avail... ZRLE: enabled Tight: DISABLED Zlib: enabled ZlibHex: DISABLED Hextile: DISABLED CoRRE: enabled RRE: enabled Raw: enabled Just for grins, I went to Screens support site to see if anybody was having the problem I was having. Sure enough somebody was. People with multiple monitors were seeing the cursor 500 pixels off. This led to the same "can't click" problem I was having. The fix was to swap monitors so that the internal monitor was on the left. I swapped position of my monitors and now I could click but my clicks were still 50 pixels off on the screen vs what I was seeing on my iPhone. Lastly I unplugged the external monitor altogether. Now everything works again (if you consider doing without my nice external monitor "working"). If you are using a VNC client to control your Mac from an iPhone or iPad and it stopped working there are two issues to look into. First there is the login change in Lion that broke all non-Apple VNC clients. You will need an updated VNC client. Second there is a BUG in Lion that affects cursor position on systems with multiple monitors. Hopefully 10.7.1 is coming to fix this soon. Until then, I gotta unplug my second monitor for VNC to work properly with my Macbook.