I am an industrial designer using an intuos pro medium, the previous generation. I can only assume that this current generation is even better.
It took some getting used to, for sure. What I discovered though, was it was mostly mental. Once I got over the hurdle of the new experience, and just sat down to get work done, I forgot that I was drawing on my tabletop while looking forward at the screen. I plan on taking a good hard look at the new iPad Pros as a possible upgrade. But you know what? The wacom tablet has done everything I've asked, and more. It's really introduced me to the world of digital sketching and I really don't need to upgrade.
If you have anymore specific questions, feel free to ask me.
Below is some sketches I did last night.