Vega 10 can be too hungry for the Tube. And too expensive to under clock. Unless the times of dual-GPU are over. A single Vega 10 could be possible. But then again, can dual Vega 11 XT still be faster combination?
Dual Vega 11 can give best perf/watt for the Tube. And perf/price as well.
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http://www.anandtech.com/show/10759/opencapi-unveiled-amd-ibm-google-more
This is what AMD and IBM would like the future to be. And quite the same what I've been writing here too: co-processors era a la Amiga is coming back. CPU's are hitting the wall, specialised co-processors are needed.