So I've been running this install of OS X for about 20 months with minimal problems. In the last few weeks though I have had some issues with it slowing down and apps not responding. Every time a quick permissions repair fixes it. In the last 3 days I have had to repair permissions 4 times. Normally it is one or two items that get fixed, usually directly related to the program in question. This morning I had 10-15 items that got fixed, most related to the library. Are there any normal reasons permissions get out of whack? This morning I deleted a bunch of podcasts from iTunes, but my iTunes library is on an external drive, Not my internal drive, where all the problems were.