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LittleSnitch (i'm paranoid ok?)
VLC (because it plays almost everything)
Aperture (faster than photoshop for pics)
iTunes (love my music)
NeoOffice (take that M$ you fscks, why i'm paraniod)
Coverflow (so I can flick through albums while iTunes visuals are playing)
Mp3Gain (levels the volume between songs)
Google Earth
Hardware Monitor
Backlight2 (to animate the desktop and shutup PC losers)
 
I don't think I saw this anywhere in this thread but one of my favorite's is:

Skitch : I love using this application to simply drag and drop random screenshots to my girlfriend or other people I am talking to on iChat... The interface is extremely easy to use and works great!

Also:

Pixelmator
Safari
iLife 08 (and iMovie 06 HD)
AppZapper
NeoOffice
Office 08 (once my school gets it in for an obnoxious price of $50!)
TaskPaper
VectorDesigner

And so many more... Software for Mac's are great! Free and the one's you have to pay for. Highly suggest getting in on the nice bundles offered up every once in a while!
 
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