Back when my 27" 4K was my main monitor, I would primarily use it at 2560x1440 and switch it to 3360x1890 when I needed additional screen real estate for web work or office tasks. No performance issues on my Mac Studio but I had issues with a 2016 MBP where it would get a bit laggy with the mouse so I had to use 1x or low resolution mode for that one.