Yes, I would have to say that my 2016 MBP with Radeon 460 does struggle somewhat to run two 5K displays plus the onboard LCD. To be honest I'm amazed it runs at all because that is a huge number of pixels (almost 35MP) for a laptop to drive. I don't run in clamshell mode so I don't know how it would be with just the two 5K's and the lid closed. I'm sure it would be better but it would still be pushing 29MP+ so I doubt it would be a massive difference. As far as I can tell, the integrated GPU shuts down when the discrete 460 GPU takes over so it's not as if the iGPU could drive the onboard LCD leaving the dGPU to drive the externals. I could be wrong but I think as soon as you connect an external display, the iGPU shuts off and dGPU takes over.
With a single 5K plus the onboard LCD it is much 'calmer'. What I mean by 'calmer' is that, when running all 3 displays, the MBP fans are spun up quite a bit even when not really doing much, and I can see from iStat Menus that it's mainly the 460 dGPU which is consuming power with the CPU largely idle. This isn't really a surprise I guess. When I disconnect the 2nd 5K display and just run one 5K plus onboard LCD, the fans spin down to a much more acceptable level.
Now, if you were to run the same scenarios with a 2018 model with the best dGPU option then it's bound to be better but how much better I can only guess. According to Geekbench OpenCL benchmarks, the Radeon Pro 560X in the 2018 model has a compute score of 58133 and my Radeon Pro 460 has a score of 52328 so it's an incremental improvement and unlikely in my opinion to radically change things. That said, the thermal architecture in the 2018 model might be more efficient at dispersing the heat which might make more of a difference than the pure compute performance.
In any event, what I have recently bought is the Blackmagic eGPU with the Radeon Pro 580 GPU the same as in the current iMac 5K (not the iMac Pro). Essentially this offloads the task of running one display to the 580 eGPU leaving the 460 dGPU to run the second 5K and onboard LCD. That gives me the screen real estate I wanted without the high fan speeds and corresponding noise or the glitchy performance. I have recently switched to the Mojave Beta and so far that's running just fine. The only slight annoyance I find with the eGPU is that many/most apps can't handle disconnection of the eGPU and you have to shut down most apps before you can undock from the eGPU and take the laptop away with you. Hopefully the most popular apps will get wise to this and fix it as eGPUs become more mainstream but that will take time I expect.
No I don't use colour calibration, as my line of work (software development) doesn't really need it. To my eye, the stock calibration of the LG 5K displays matches my MBP really well. If I view the same photo on the various displays it looks very very close to identical. They all support DCI-P3 and since Apple had a hand in developing the LG 5K and it has the same LCD panel as the iMac 5K, this isn't surprising I don't think.
I hope this info helps but ultimately only you can decide. Hopefully you are in a position where you can make use of Apple's 14 day return period to evaluate the setup in your own environment. Good luck!