But it's not like your losing USB ports with the wireless.
It's all the same either way.
The wired mouse and keyboard take up two USB ports combined, but have the two on the keyboard that I personally wouldn't use anyways.
And with the wireless, there isn't any USB ports on the keyboard itself, but it allows for the two on the computer to be open for use.
I think the Wireless is the way to go if your not worried about loss of buttons. 🙂
It's down to if you want a sleeker look, or not..basically.