Lately, ever since I received my new 4S and turned on wireless syncing, I've been getting this CONSTANTLY. I'll click on something in iTunes (like a different menu item), and it asks me if I want to apply changes to my iPhone. Thing is, I haven't made any changes! I can reproduce it easily, every time. Just go into iTunes, click on the device, and then click "Sync." After the sync is done and I click off of the iPhone, it asks me this. I can then go do another sync, having made no settings changes, and again after clicking off of the iPhone, it asks me if I want to apply changes. It's driving me crazy! The weird thing is, I also have an iPad, and it doesn't do it for that device. ? They're both running 5.0.1 (and it's been happening ever since 5.0).