They have transposed some comic character personalities and/or events to others. Deviations have been significant but the overall framework and tone has been preserved.
Deviating from the original story that I like works for me if they don't go too far with the changes. I can enjoy TWD and X-Men, despite differences, but True Blood was over the top for me.
Don't even get me started on True Blood. Man Ball (the creator of the show) destroyed that show. He literally ruined it. If any of you have been to SDCC where he has spoken, he is liked because he brought the show to HBO, but he is panned because he has deviated so much from the books. Heck even Charline Harris doesn't want anything to really do with the shows. Except the money of course.
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Short answer: no with qualifiers. I consider the following spoiler a mild one.
Spoiler
Terminus is not in the comic, however in the comic after they arrive in D.C., they run into a bad group of people who live in a fortified factory, which this looks suspiciously like. And I don't remember it being called Terminus in the comic. Are the producers messing around with comic readers or is this a major juxtaposition of the story? Only time will tell.
Are you talking about "The Alexandria Safe Zone"?