It's something that you will slowly get used to over the course of 2-3 weeks. I did experience a fairly severe eye strain initially (would get headaches after looking at the screen for just over an hour), but that soon eased as my eyes quickly got used to the new resolution. Now, I can stare at the screen all day with no issues.
For me, the text in ms office is too small, I typically work at 200% magnification if I want to see anything properly. The upside is that the screen is big enough to allow me to work with 2 documents open side by side. The downside is that when I open those documents on my laptop, I then need to reduce their size because they open at 200% size! (And this means when I re-open the same document, I need to increase the size again, and pinch-to-zoom doesn't work.
For webpages, you can zoom to a comfortable size, so that is generally not an issue. I sometimes find tab sizes and addresses too small to see at a glance, but that doesn't really bother me enough.
Default folder size may also be too small, this can be readily adjusted, but again, can be irritating.
Overall, no long-lasting problems.