Blocking activation does not block Adobe's sites.
Actually, there are some that do. It depends on where you got the list from, and of course which URLS it says to block. I found that at least one of them, that is not simply adobe.com will make whatever web browser you're using throw up an error about it not being able to connect to it.
I really hope they lower the price for CS6. I don't think Adobe understands that programs like Dreamweaver, Illustrator, and InDesign, aswell as Photoshop are some of the best creative software out there for the average consumer.
And with these prices, they are continuing to lose their base of potential users who are now going to alternatives. I personally don't use Dreamweaver anymore because I have Espresso that is so much better in comparison and cheaper. Pixelmator could be the next thing to take me away from Photoshop. What next? Clearly there's going to be a new boom of new developers on the Windows 8 side and I think Adobe needs to step up and bring us Adobe Touch quality work, with more options and a $100 or less price tag.