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Safari's been my main web browser for years now. And I've never had any serious trouble with it. I run safari 5.1 with an adblocker and auto refresh plug in and it runs perfectly!
 
Safari 5.1's working fine for me on Lion (no extensions needed either). I've never had a problem and I'm using a Mac from the 2009 series. I used to keep other browsers for web prototyping but now just use BrowserLabs. So Safari's my only web browser.
 
I'm now using Safari 5.1 wit AdBlocker following Lion install mostly due to the benefits of gestures and full-screen. Seems to work Ok for me.
 
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