Not in the web browser. Though most sites seem to use HTML5 or Flash for playing videos nowadays, it's occasionally handy to have QuickTime. Other random things depend on it too.Honestly not much of a loss, VLC Media Player can play all QuickTime content to my knowledge.
I wish QuickTime were the most widely adopted standard. The plugin is much nicer and way, way more efficient than HTML5 or Flash for playing videos. Doesn't seem that Safari and Chrome's native WebM support is any faster. YouTube almost chokes up a low-end PC nowadays. I've got Click2Flash forcing YouTube videos to play using QuickTime instead.
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