This isn't just a slippery slope towards "Microsoft Security Essentials", this already is Apple's pendant to "Windows Defender". Integrating something similar to MSE would just be the next logical - and necessary - step.
In every black hat hacking competition, OS X always is the first OS that gets successfully hacked. Apple dumbed down the powerful Unix foundation a bit too much to let OS X still be a truly secure platform. Heck, Apple even de-activates the firewall in the default settings. Doesn't that make you feel safe already?
Trojans have become an everyday reality on OS X, and it just doesn't matter whether such a trojan requires the user's authorization to be installed. Most users are IT-illiterate enough to simply click "yes" on everything that pops up - it's a simple truth of life, end of story.
You also don't need to mention the lack of viruses on OS X. Viruses have long disappeared from the Windows landscape, too. Most malware on Windows are also trojans and maybe there are a few worms still active. (A worm is a standalone program that usually replicates itself over the network by exploiting known security holes; a virus would usually try to attach itself to a program). W32.Blaster was the last evil worm I've heard about - and encountered myself - and that was back in 2003. Since then, malware usually comes in the form of trojans. And those things are now being written for OS X as well.
OS X has become a targeted main stream platform. It's a sign of stupid arrogance and ignorance when someone pretends that it's a super-safe and malware-free platform. I doubt that OS X Mountain Lion is any safer than Windows 8 (which has MSE and other defense mechanisms built in and also has an activated firewall); and it's definitely not safer than any current Linux or BSD distribution. The argument that Linux has an irrelevant market share on the desktop would be invalid: Linux runs on most servers on the Internet and all desktop versions of Linux use the same foundation as their server siblings.
Using the Mac App Store as the sole distribution channel for software wouldn't really fix the problem. Firstly, this solution comes at the price of the user's freedom. I don't know about you, but I find a platform that forces me to buy and download software from one single source completely unacceptable. Secondly, going down that route --might-- provide some protection against trojans (as long as the software does not download additional content from an unknown location), but it won't protect you against worms or other software that uses security holes to upload and install itself. It also won't protect you against browser exploits. Remember that you only needed to visit jailbreakme.com to jailbreak your iPhone?