use Little Snitch (on Mac) or Zone Alarm (on PC) you can block:
"www.ad*"
"ad*"
"www.ad.*"
"ad.*"
"www.ads*"
"ads*"
"www.ads.*"
"ads.*"
and on Cydia you can use Firewall IP to do the same.
That should get you started, then just look for other addresses you are getting ads from, or use google for a more comprehensive list.