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I use Monster Screen Cleaner and a microfiber cloth to clean the screen, palm rest, keyboard... well... everything really. Works great.

I do that about once every week. I shut er down and clean it up, then boot up again. It's a good feeling. Kind of like an enema.

Enema. LOL :D
 
I wipe my MacBook with a damp cloth every couple weeks to remove dirt and grime (it's white and shows everything, as one would expect). Aside from that, though, I'm not particularly anal. My Mac-using friends with MacBook Pros, on the other hand, each of them practically handle their machines with white gloves. :p
 
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